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re. The severe form of the illness, dengue haemorrhagic fever, can result in significant bleeding, a sharp drop in blood pressure, shock, and even death. Most often, the virus is found in tropical and subtropical areas, such as Central and South America, Africa,
some parts of Asia, and the Pacific Islands. Except for when a pregnant woman transmits the disease to her unborn child, dengue is not communicable from person to person.
According to research, about 400 million people contract dengue each year, but the majority (almost 80%) show no symptoms. Once you've had the dengue virus, you can develop immunity to that particular strain. This is quite hard because the virus (DENV) has at least four different strains. Your immune system can identify illnesses and develop more effective defences against them with the help of certain instruments. Your body searches through its
arsenal to identify the instrument (antibody) that can neutralise that specific threat when it battles a virus.

What is Dengue Duo Rapid Test?

A qualitative immunochromatographic technique called the Dengue Duo Panel can concurrently identify anti-dengue IgG/IgM antibodies and Dengue NS1 antigens in human blood, serum, and plasma specimens. The goal of the test results is to help with dengue infection diagnosis. The detection of both NS1 antigen and anti-Dengue antibodies provides a technique for diagnosing dengue infection from the early stages of infection to the stage
after sickness onset. It has the potential to improve the accuracy of dengue infection diagnosis.
The Dengue Duo Rapid Test is used for below reasons:

• All four dengue serotypes are detected.
• The duo test format reduces processing time.
• The presence of IgM implies a recent infection.
• The presence of IgG antibodies indicates a recent or previous infection.
• The presence of Ag implies a present infection.

How Dengue Fever Is Caused?

Four dengue viruses cause Dengue fever. When a mosquito carrying the dengue virus bites you, the virus can reproduce itself in your blood. You may feel ill as a result of both the infection and the immune system's reaction. The virus can obliterate components of your blood that help clot and give your blood vessels shape. This can make your blood seep out of your vessels and cause internal bleeding, combined with specific chemicals that your
immune system produces. This results in severe dengue's potentially fatal symptoms. Dengue is spread by Aedes mosquitos, which also carry viruses such as Zika and chikungunya. The mosquito bites someone with dengue fever and then bites someone else, infecting them.

Symptoms Where a Dengue Duo Rapid Test is Required

Most dengue infections do not show any symptoms. Symptoms like the below need a
Dengue Duo Rapid test.

• Rash
• A sharp discomfort behind your eyes
• Vomiting or nausea
• Pain in the muscles, bones, and joints
• Abdominal or stomach ache
• Excessive vomiting
• Blood during vomiting or stool
• Bleeding gums or nose
• Extreme exhaustion, agitation, or irritation

When a patient presents themselves in a clinical environment, laboratory testing is crucial to making an accurate diagnosis of acute dengue virus infection so that the patient can receive the proper care.

How Dengue Duo Rapid Test is Performed?

The dengue virus (DENV) is the virus that causes dengue. There are four DENV serotypes, which means that a person could contract the virus four times. The test is intended to identify dengue infection within a two-week window, particularly when the NS1 test becomes ineffective at identifying the virus. NS1 tests find the dengue virus' non-structural protein NS1. When dengue is present, this protein is produced in the blood. For usage in serum,
NS1 assays have been developed. Most of these tests use synthetically labelled antibodies to detect dengue NS1 protein.
The dengue NS1 test examines the patient's blood for viral proteins (or antigens). When you are in the active stage of dengue illness, it is utilised within the first 0-7 days of symptom onset. After the seventh day of symptoms, a dengue NS1 test is no longer considered trustworthy.

Test Procedure

• A blood test is used to identify dengue disease.
• Your medical provider will draw blood from you and send it to a lab to be analysed for dengue virus symptoms.
• The four variants you have may also be determined by this.
• To check for additional viruses that cause comparable symptoms, your doctor may order a blood test.

These tests use lateral flow immunochromatography to get results in 10-20 minutes, depending on the test. Because the Dengue Duo Rapid Tests may be stored at room temperature, they are cost-effective for long-distance transportation and storage. The technique for the Dengue Duo Rapid Test is easy and simple.

Interpreting & Understanding Dengue Duo Rapid Test Results

From Day 1 to Day 9 after the onset of clinical symptoms, dengue can be detected early. A suspected case of dengue fever can have at least one of the following tests to confirm the diagnosis:

• ELISA demonstration of NS1 antigen
• IgM antibody titre demonstrated by ELISA in a single blood sample
• IgG seroconversion in matched sera after two weeks with a four-fold increase in titre
• Viral nucleic acid demonstration by PCR

In samples of acute-phase serum, the level of NS1 Ag ranges from 0.5-2 µg/ml to less than 0.04 µg/ml. If the test is positive, you have likely contracted the dengue virus. Negative results may indicate that you are not infected or that you were tested too recently for the virus to manifest itself. When you get suspected of dengue fever get tested., Dengue has no cure, but an early discovery and testing can save lives. If you have dengue symptoms, it is critical to know which tests you need and when to get them.

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